The synthesis of higher glycerides via the monoglyceride pathway in hamster adipose tissue.

نویسندگان

  • F M Schultz
  • J M Johnston
چکیده

The monoglyceride pathway for the synthesis of triglycerides has been investigated employing subcellular fractions and whole cell preparations of white and brown adipose tissue. Conclusive evidence has been obtained for the monoglyceride pathway in these tissues by employing the 2-monoether analogue of 2-monoolein as the substrate. The monoglyceride and alpha-glycerophosphate pathways were primarily found in the microsomal fraction. In these in vitro systems the activity of the monoglyceride pathway compared with the alpha-glycerophosphate pathway was of the same order of magnitude in whole cell preparations and was approximately one-half the activity of the alpha-glycerophosphate pathway when the microsomal fraction was employed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Acceptors of fatty acid for glyceride synthesis in guinea pig mammary gland.

T w o PATHWAYS have now been described for the biosynthesis of glycerides in mammalian tissues. In the pathway which exists in liver (1, 2) and adipose tissue (3), triglycerides are synthesized from L-a-glycerophosphate via L-a-phosphatidic acids and D-a,@-diglycerides. More recently it has been found that a second pathway involving the direct acylation of monoglyceride exists in intestinal muc...

متن کامل

Spermatogenesis after transplantation of adipose tissue-derived mesenchymal stem cells in busulfan-induced azoospermic hamster

Objective(s): Adipose tissue-derived mesenchymal stem cells (AT-MSCs) with more potent immunomodulatory effects, greater proliferative potential and secretion of growth factors and cytokines in comparison with bone marrow derived MSCs are more appropriate for cell therapy. The aims of the present study were to evaluate the histomorphometric effect of AT-MSCs allotransplantation on regeneration ...

متن کامل

Fine Structural Localization of Acyltransferases

A study of the fine structural localization of the acyltransferases of the monoglyceride and alpha-glycerophosphate pathways for triglyceride synthesis in the intestinal absorptive cell is reported. Glutaraldehyde-fixed tissue was found to synthesize diglyceride and triglyceride from monopalmitin and palmityl CoA, and parallel morphological studies showed the appearance of lipid droplets in the...

متن کامل

Comparison of Epicardial Adipose Tissue Fatty Acid Profile in Cardiovascular Disease Patients Diabetic and Non-Diabetic

ABSTRACT         Background and Objective: The relationship between diabetes mellitus and increased risk of cardiovascular diseases has been demonstrated. The aim of this study was to determine the fatty acid profile of epicardial adipose tissue in diabetic and non-diabetic patients with cardiovascular disease.       &nb...

متن کامل

Functions of Obesity-related Hormones in Breast Cancer: A Review

ABSTRACT            Obesity is a health problem defined as abnormal or excessive fat accumulation in adipose tissue. Adipokines such as adiponectin, visfatin and resistin are bioactive polypeptides with pro- and anti-inflammatory properties that are secreted by the adipose tissue that are involved in the pathogenesis and prognosis of diseases ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of lipid research

دوره 12 2  شماره 

صفحات  -

تاریخ انتشار 1971